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Dr. Lai Wai Kwan Vincent

Consultant Gastroenterologist & Hepatologist

MBChB (Sheffield)
MRCP (Edinburgh)
PhD (Birmingham)

CCT (UK)
Specialist Register (UK)
Consultant Gastroenterologist

MBChB (Sheffield)
MRCP (Edinburgh)
PhD (Birmingham)
CCT (UK)
Specialist Register (UK)
Consultant Gastroenterologist

Clinical Interests:

Language Spoken:

About Dr. Vincent Lai:

Dr. Vincent Lai attained his medical degree from the University of Sheffield, England, in 1993. He underwent five years of specialist training in Gastroenterology, followed by an additional five years of sub-specialization in Hepatology at Birmingham, UK—home to one of the largest Liver Transplant Units in Europe. His expertise spans general and transplant hepatology, with a focus on managing acute liver failure and viral hepatitis.

Dr. Lai has received extensive training in diagnosing and treating gastrointestinal and liver conditions. In 2002, he was awarded the prestigious Medical Research Council Clinical Training Fellowship and later obtained a Ph.D. from the University of Birmingham in 2007, researching liver immunity in viral hepatitis.

Professional Experience:

Dr. Lai was accredited by the Specialist Accreditation Board in Gastroenterology (England) in 2006 and served as a Consultant Hepatologist at Derby NHS Foundation Trust Hospital (2006-2008). During this period, he played a crucial role in enhancing viral hepatitis services, securing research grants, and contributing to medical studies.

Upon returning to Singapore in 2008, Dr. Lai has been actively involved in both cadaveric and living donor liver transplantation. His extensive research contributions include publications in viral immunology and acute liver failure.

Research & Expertise:

Dr. Lai specializes in:

With his vast experience in hepatology and transplant medicine, Dr. Lai remains committed to providing advanced care and research-driven treatments for patients with complex liver conditions.

Associated Overseas Partners:

Accredited Singapore Hospitals:

Publications:

Lim SG,Aung MO,Mak B, Sutedja D, Lee YM, Lee GH, Fernandes M, Low HC, Lai V, Dan YY. Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis. J Clin Gastroenterol. 2011 Oct;45(9):818-23.
https://pubmed.ncbi.nlm.nih.gov/21921845/

Lim LG, Tan XX, Woo SJ, Dan YY, Lee YM, Lai V, Lim SG. Risk factors for mortality in cirrhotic patients with sepsis. Hepatol Int. 2011 Sep;5(3):800-7. Epub 2011 Feb 13.
https://pubmed.ncbi.nlm.nih.gov/21484126/

Lo R, Lai V. Medical image. An unusual cause of left iliac fossa mass. N Z Med J. 2008 Sep 22;121(1282):74-5.
https://pubmed.ncbi.nlm.nih.gov/18815608/

Alabraba EB, Lai V, Boon L, Wigmore SJ, Adams DH, Afford SC. Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion. Hepatology. 2008 Feb;47(2):552-62.
https://pubmed.ncbi.nlm.nih.gov/17999420/

Alabraba EB, Curbishley SM, Lai WK, Wigmore SJ, Adams DH, Afford SC. A new approach to isolation and culture of human Kupffer cells. J Immunol Methods. 2007 Sep 30;326(1–2):139–44
https://pubmed.ncbi.nlm.nih.gov/17692868/

Lai WK, Curbishley SM, Goddard S, Alabraba E, Shaw J, Youster J, McKeating J, Adams DH. Hepatitis C is associated with perturbation of intrahepatic myeloid and plasmacytoid dendritic cell function. J Hepatol. 2007 Sep;47(3):338–47
https://pubmed.ncbi.nlm.nih.gov/17467113/

Thurairajah PH, Thorburn D, Hubscher S, White A, Lai WK, O’Donnell K, Mutimer D. Incidence and characterization of serum transaminases elevations in pegylated interferon and ribavirin treated patients with chronic hepatitis C. Aliment Pharmacol Ther. 2007 Jun 1;25(11):1293-300
https://pubmed.ncbi.nlm.nih.gov/17509097/

Lalor PF, Lai WK, Curbishley SM, Shetty S, Adams DH. Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo. World J Gastroenterol. 2006 Sep 14;12(34):5429–39
https://pubmed.ncbi.nlm.nih.gov/17006978/

Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am J Pathol. 2006 Jul;169(1):200–8
https://pubmed.ncbi.nlm.nih.gov/16816373/

Heydtmann M, Freshwater D, Dudley T, Lai W, Palmer S, Hübscher S, Mutimer D. Pegylated interferon alpha-2b for patients with HCV recurrence and graft fibrosis following liver transplantation. Amer J Transplant. 2006 Apr;6(4):825–33
https://pubmed.ncbi.nlm.nih.gov/16539640/

Zhang WX, Lai V, Mutimer D, Mirza D. Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants. Hepatobiliary Pancreat Dis Int. 2006 Feb;5(1):154–6
https://pubmed.ncbi.nlm.nih.gov/16481305/

Lai W, Smith A, Raman V, Thorburn D. Severe hepatic injury resulting from N-nitrosofenfluramine adulteration of traditional Chinese medicines used as weight loss aids. BMJ. 2006 Feb 4;332(7536):304–5
https://pubmed.ncbi.nlm.nih.gov/16455741/

Lai W, Haydon G, Mutimer D, Murphy N. The effect of molecular adsorbent recirculating system on pathophysiological parameters in patients with acute liver failure. Intensive Care Med. 2005 Nov;31(11):1544–9
https://pubmed.ncbi.nlm.nih.gov/16155752/

Shah T, Lai W, Gow P, Leeming J, Mutimer D. Low dose amphotericin for prevention of serious fungal infection following liver transplantation. Transpl Infect Dis. 2005 Sep-Dec;7(3-4):126–32
https://pubmed.ncbi.nlm.nih.gov/16390401/

Shah T, Lai W, Mutimer D. Impact of targeted oral ganciclovir prophylaxis for transplant recipients of livers from CMV-seropositive donors. Transpl Infect Dis. 2005 Jun;7(2):57–62
https://pubmed.ncbi.nlm.nih.gov/16150091/

Lai W, Adams D. Angiogenesis and chronic inflammation; the potential for novel therapeutic approaches in chronic liver disease. J Hepatol. 2005 Jan;42(1):7–11
https://pubmed.ncbi.nlm.nih.gov/15629498/

Lai WK, Murphy N. The management of acute liver failure. Contin Educ Anaesth Crit Care Pain. 2004 4:40–43
https://www.e-safe-anaesthesia.org/e_library/11/Management_of_acute_liver_failure_CEACCP_2004.pdf

Lai WK, Morice AH. A fatal case of Varicella-Zoster infection in a steroid dependent asthmatic receiving methotrexate. Thorax. 1995 50;1221–2
https://pubmed.ncbi.nlm.nih.gov/8553283/