Drug Induced Liver Injuries

Drug-induced liver injury (DILI) refers to liver damage caused by medications, herbal products, or dietary supplements. It can range from mild enzyme elevation to severe liver failure. DILI is classified into two types:

1. Intrinsic DILI: Predictable and dose-dependent, such as acetaminophen toxicity.
2. Idiosyncratic DILI: Unpredictable and not dose-dependent, often linked to individual genetic or immune responses.

Symptoms

• Jaundice (yellowing of the skin and eyes)
• Fatigue and weakness
• Abdominal pain
• Nausea and vomiting
• Dark urine or pale stools

Diagnosis and Treatment

• Diagnosis involves identifying the offending drug and ruling out other causes of liver damage.
• Treatment typically includes discontinuing the drug and supportive care. In severe cases, liver transplantation may be necessary.

Preventive measures include careful monitoring of liver function during medication use and avoiding unnecessary or high-risk drugs.